Tokyo, Japan, January 30, 2023 --- Teijin Pharma Limited, the core company of the Teijin Group’s healthcare business, announced today that on January 30 the company will begin selling abaloparatide acetate for osteoporosis under the tradename OSTABALO® Subcutaneous Injection Cart 1.5mg will be priced at JPY 16,128.
The drug, which Teijin Pharma is positioning as a strategic product for robust market penetration, is a new osteoplasty accelerator that embodies the company’s extensive experience with treatments for bone and joint diseases.
OSTABALO® Subcutaneous Injection Cart 1.5mg is a self-administration drug indicated for patients with osteoporosis at high risk of fractures. The active ingredient is abaloparatide acetate, a polypeptide containing a modification of one part of the 34 amino acid sequences from the N-terminus of human parathyroid hormone-related protein. Abaloparatide acetate selectively stimulates RG-type parathyroid hormone type 1 receptors involved in bone metabolism. It is a novel bone anabolic agent with a predominant effect on bone formation over bone resorption, helping to prevent bone fractures. The drug can be taken once daily (80μg) by adults for up to 18 months, administered subcutaneously via aqueous injection (cartridge) using an exclusive electronic injector, named the OSTABALO® Injector.
The efficacy and safety of abaloparatide acetate have been confirmed in clinical trials in Japan and worldwide involving osteoporosis patients with high risk of bone fractures. In April 2017, the U.S. Food and Drug Administration (FDA) granted approval to Radius Health, Inc. for the use of abaloparatide under the trade name of Tymlos® in U.S. in treating osteoporosis in postmenopausal women who are at high risk of fracture. For deployment in Japan, Teijin Limited, the parent company of Teijin Pharma, signed a license agreement with Radius in July 2017 and the two companies have been partnering for development and sales in Japan for OSTABALO®.
According to a medical literature “2015 Guidelines for Prevention and Treatment of Osteoporosis,” Japan is estimated to have about 13 million patients with osteoporosis, many of whom are at risk of bone fractures that could greatly reduce their activities of daily living and quality of life. Osteoporosis is particularly troublesome for those with low bone density, bone fragility or a high frequency of fractures due to aging. There is strong demand in Japan for therapeutic drugs capable of increasing bone mass quickly to help patients avoid debilitating bone fractures.
Teijin Pharma is helping to improve patients’ quality of life through solutions that address problems with bones and joints, including through the company’s osteoporosis drugs ONEALFA® and BONALON® (*) and sonic accelerated fracture healing system SAFHS® . Teijin Pharma is committed to enhancing patients’ quality of life by providing new treatment options for diseases with high unmet needs.
(*) BONALON®: Registered Trademark of NV Organon
About the Teijin Group
Teijin (TSE: 3401) is a technology-driven global group offering advanced solutions in the fields of environmental value; safety, security and disaster mitigation; and demographic change and increased health consciousness. Originally established as Japan's first rayon manufacturer in 1918, Teijin has evolved into a unique enterprise encompassing three core business domains: high-performance materials including aramid, carbon fibers and composites, and also resin and plastic processing, films, polyester fibers and products converting; healthcare including pharmaceuticals and home healthcare equipment for bone/joint, respiratory and cardiovascular/metabolic diseases, nursing care and pre-symptomatic healthcare; and IT including B2B solutions for medical, corporate and public systems as well as packaged software and B2C online services for digital entertainment. Deeply committed to its stakeholders, as expressed in the brand statement “Human Chemistry, Human Solutions,” Teijin aims to be a company that supports the society of the future. The group comprises some 170 companies and employs some 20,000 people across 20 countries worldwide. Teijin posted consolidated sales of JPY 926.1 billion (USD 7.2 billion) and total assets of JPY 1,207.6 billion (USD 9.4 billion) in the fiscal year that ended on March 31, 2022
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