Based in Newton, Massachusetts, Macrolide Pharmaceuticals focuses on the discovery and development of novel macrolide antibiotics for the treatment of life-threatening bacterial infections caused by drug resistant pathogens. Using novel technology, Macrolide Pharmaceuticals can synthesize a broad range of macrolides, and initial compounds show promising anti-bacterial activity. The company seeks to extend the anti-bacterial spectrum of the macrolide class, both in Gram-negative infections d and Gram-positive organisms. The synthetic technology provides a platform for the creation of multiple antibiotic products.
Macrolide Pharmaceuticals’ strategy is based on unique chemistry developed by Prof. Andrew Myers of Harvard University. Prof. Myers has developed the first practical total synthesis of the macrolide class of antibiotics from basic building blocks. The macrolide class is among the most successful antibiotic classes, but it has been limited by semi-synthesis so only a handful of macrolides have been commercialized since erythromycin was discovered in 1948.
Gurnet Point Capital co-led the Series A financing of Macrolide Pharmaceuticals in March 2015.